Necrolytic migratory erythema is a cutaneous reaction pattern with specific histopathologic features tures that is typically associated with a functioning pancreatic islet cell neoplasm such as a glucagonoma. However, cases without glucaggonoma
have
also been reported, such as, liver cirrhosis, chronic pancreatitis, celiac sprue etc. Other clinical features include anemia, glossitis and weight loss.
We report a case of necrolytic migratory erythema induced by a pancreatic insufficiency without glucagonoma.
A 43-year-old male was seen at our department because of multiple erythematous, desquamative and erosive patches on the whole body for 1 month. He also had weight loss(25kg) and stomatitis. Seven years previously he had a Whipple's procedure for
a
pancreatic head rupture. The laboratory data showed a low protein and zinc level, and high glucagon. Level. Histopathologic findings of the case showed epidermal edema and pallor, and superficial epidermal necrosis. The patient improved
proggessively
after intravenous infusion of amino acids with a pancreatic enzyme supplementation. (Kor J Dermatol 1996;34(1) : 166~170)
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